THPdatabase The dominant search intent revolves around finding databases that catalog therapeutic peptides, particularly those approved by regulatory bodies like the FDA.a database of structurally annotated therapeutic peptides. Users are looking for comprehensive resources that provide detailed information about these peptides, their structures, applications, and potentially their developmentPlantPepDB: A manually curated plant peptide database.
Tier 1:
* Core Entities: Therapeutic peptides, databases, FDA-approved peptides
* High-Relevance Phrases: therapeutic peptides database, FDA approved therapeutic peptides, database of therapeutic peptides, approved therapeutic peptides
Tier 2:
* Supporting Databases: THPdb, THPdb2, SATPdb, PepTherDia
* Attributes/Details: structurally annotated, experimentally validated, protein therapeutics, therapeutic targets, antimicrobial peptides, plant peptides
* Related Concepts: peptide design, peptide sequence, peptide structure, peptide development
Tier 3:
* Less Relevant/Redundant: executables, python source codes, prebuilt databases, PNA is an artificial nucleic acid with a peptide backbone, therapeutic goods administration, metabolite identification, specific numbers of entries without context, commercial product names unless directly related to a databaseTherapeutic Goods Administration (TGA) | Australian ....
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Navigating the landscape of therapeutic peptides requires access to specialized databases that consolidate critical information. A therapeutic peptides database serves as an essential resource for researchers, clinicians, and developers seeking detailed insights into these complex molecules. Specifically, databases focusing on FDA approved therapeutic peptides are of paramount importance, providing validated information on compounds that have met rigorous regulatory standards for human use作者：D Das·2020·被引用次数：124—PlantPepDBis a web-based repository dedicated to plant peptides. It consists of 3848 manually curated plant peptide entries and various search .... These curated repositories offer a centralized point for understanding the properties, applications, and developmental status of a wide array of therapeutic peptides.Database of FDA-approved peptide and protein therapeutics.
Several prominent databases have emerged to catalog therapeutic peptides, each with its unique focus and scopeTherapeutic Goods Administration (TGA) | Australian .... Among the most frequently referenced are:
* THPdb (Therapeutic Human Peptide Database): This database is a well-established repository that compiles information on FDA-approved and investigational therapeutic peptides作者：B Xiao·2025·被引用次数：3—This paper presents a comprehensive dataset comprising 58,583 experimentally validatedtherapeutic peptideswith annotated structure .... It is known for its manual curation and provides essential details on peptide sequences, structures, and functional annotations. THPdb aims to offer a comprehensive overview of therapeutic peptides and proteins that have received regulatory approval or are undergoing clinical evaluation.
* THPdb2: An evolution or related project to THPdb, THPdb2 continues the effort to compile FDA-approved therapeutic peptides and proteins. These databases are invaluable for tracking the approved peptide therapeutics, offering user-friendly search functionalities to access specific data points.
* SATPdb (Structurally Annotated Therapeutic Peptides Database): SATPdb distinguishes itself by focusing on structurally annotated therapeutic peptides. This database is curated from numerous public domain peptide databases and datasets, aiming to provide a rich source of information on the structural characteristics of therapeutic peptides作者：V D’Aloisio·2021·被引用次数：135—PepTherDia is a database containing 105 approved peptide pharmaceuticals. 86% of approved peptide therapeutics and diagnostics are natural or naturally-derived.. Understanding the structure is crucial for comprehending a peptide's function and for designing new therapeutic agents.
* PepTherDia: This database specifically focuses on approved peptide pharmaceuticals and diagnostics作者：S Singh·2016·被引用次数：268—A database of structurally annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets including 9 of our own.. It highlights that a significant percentage of approved peptide therapeutics are derived from natural sources, underscoring the importance of natural product discovery and modification in peptide drug development.This review examines the fundamental aspects of current DGMs for designingtherapeutic peptidesequences. First, relevantdatabasesin this field are introduced ...
* DBAASP (Database of Antimicrobial Activity and Structure of Peptides): While not exclusively focused on FDA-approved therapeutic peptides, DBAASP is a significant resource for antimicrobial peptidesSATPdb is a database of structurally annotated therapeutic peptidescurated from twenty public domain peptide databases and two datasets. These peptides have .... It provides manually curated data on the activity and structure of these peptides, which are an important class of therapeutics with growing potentialTHPdb2: compilation of FDA approved therapeutic ....
Beyond simply listing approved peptides, these databases offer a wealth of information crucial for scientific advancement and drug development. Users can typically find details on:
* Peptide Sequences and Structures: The precise amino acid sequence and, where available, three-dimensional structural information are fundamental. This data is essential for understanding how a peptide interacts with its biological targets.thpdb
* Therapeutic Applications and Indications: Information on the diseases or conditions each peptide is designed to treat, along with its mechanism of action.
* Regulatory Status: Clearly identifying whether a peptide is FDA-approved, investigational, or has been withdrawn from the market.
* Developmental Pathways: Some databases may include information on clinical trial phases, sponsors, and related research.SATPdb is a database of structurally annotated therapeutic peptidescurated from twenty public domain peptide databases and two datasets. These peptides have ...
* Annotation and Curation: The quality of a database is often determined by its curation processTHpdb - Database Commons. Manually curated databases, like THPdb and DBAASP, generally offer higher reliability and accuracy by expert review.
* Experimental Validation: Databases that include experimentally validated therapeutic peptides with annotated structures provide a robust foundation for research.
The inclusion of "FDA approved" in many database titles highlights the critical role of regulatory bodies in the therapeutic peptide landscape.a database of structurally annotated therapeutic peptides. The rigorous evaluation process by the U.S. Food and Drug Administration (FDA) ensures that therapeutic peptides meet stringent standards for safety, efficacy, and quality. Databases focusing on these approved agents provide a reliable reference for established treatments and serve as a benchmark for ongoing research and development.SATPdb Home Page: A Database of Structurally Annotated ... Similarly, other regulatory agencies, such as Australia's Therapeutic Goods Administration (TGA), play a vital role in assessing and monitoring therapeutic products.The current version of thedatabaseholds a total of 852 entries, providing comprehensive information on 239 US-FDA approvedtherapeutic peptidesand ...
The field of therapeutic peptides is dynamic, with ongoing research into novel peptide designs, delivery systems, and applications. Databases are continually updated to reflect new discoveries and approvals. Emerging trends include the development of peptide-based treatments for a wider range of diseases, including cancer, metabolic disorders, and infectious diseases作者：SS Usmani·2017·被引用次数：607—THPdb(http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins.. Furthermore, advancements in computational tools and artificial intelligence are contributing to the design and discovery of new therapeutic peptides, which will undoubtedly be reflected in future iterations of these valuable databases. The integration of data from various sources, such as structurally annotated therapeutic peptides and experimental validation datasets, will continue to enhance the depth and utility of these resources.
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