SS-31 peptidebodybuilding
Peptide SS-31, also known by its investigational drug name Elamipretide, is a synthetic tetrapeptide that has garnered significant attention for its ability to target and accumulate within mitochondria, the powerhouses of our cells.SS-31 (also known as Bendavia, Elamipretide, and MTP-131) isa small peptide that accumulates in mitochondria and scavenges reactive oxygen species. This mitochondria-targeting peptide is designed to enhance mitochondrial function, reduce oxidative stress, and promote cellular repair. By specifically interacting with cardiolipin on the inner mitochondrial membrane, SS-31 plays a crucial role in stabilizing the electron transport chain (ETC) and mitigating the production of harmful reactive oxygen species (ROS). Its potential applications span various aging-related conditions and diseases characterized by mitochondrial dysfunction.
The primary mechanism of action for SS-31 revolves around its selective localization within mitochondria. Once inside, it binds to cardiolipin, a vital phospholipid found almost exclusively in the inner mitochondrial membrane. This binding is critical for stabilizing the structure and function of the ETC, the system responsible for generating the majority of cellular energy in the form of ATP.作者：MT Sweetwyne·2017·被引用次数：113—Elamipretide (SS-31) is a mitochondria-targeted tetrapeptide that selectively interacts with cardiolipin on the inner mitochondrial membrane.SS-31enhances ... By optimizing ETC efficiency, SS-31 helps to improve energy production and reduce the leakage of electrons, which is a major source of ROS. This reduction in mitochondrial ROS production is a key protective effect, preventing cellular damage and inflammation associated with aging and various pathologies.
The unique properties of SS-31 have opened doors to its exploration in a wide range of therapeutic areas.SS-31, MOTS-c help with Mitochondrial function and aging Research indicates its potential to ameliorate conditions linked to mitochondrial dysfunction and oxidative stress.
* Aging and Age-Related Diseases: SS-31 is being investigated for its ability to counteract multiple age-related changes. By restoring redox homeostasis and improving mitochondrial quality, it may enhance physiological function and resilience against the effects of aging.
* Cardiovascular Health: Studies suggest that SS-31 can protect the heart from damage and improve its function, particularly in conditions like heart failure.
* Kidney Protection: The peptide has demonstrated efficacy in protecting kidney tissues from injury and improving function in various models of kidney disease.
* Neurological Disorders: Its ability to cross the blood-brain barrier and target mitochondria in the brain makes it a candidate for treating neurodegenerative diseases characterized by mitochondrial impairment.
* Barth Syndrome: Elamipretide (SS-31) has been developed as a treatment for Barth syndrome, a rare genetic disorder affecting mitochondrial functionElamipretide.
While SS-31 is a prominent example, other peptides also target mitochondrial functionElamipretide (Brand Name FORZINITY™ for Barth .... For instance, MOTS-c is another peptide that has shown promise in improving mitochondrial health and metabolic regulation. However, SS-31 distinguishes itself through its specific interaction with cardiolipin and its well-documented effects on the electron transport chain. The precise chemical structure of SS-31, a tetrapeptide with an alternating aromatic and amino acid sequence, contributes to its cell permeability and selective accumulation in mitochondria.
As a therapeutic agent, SS-31 is undergoing rigorous clinical trials.作者：AJ Reiffel·2011—TheSzeto-Schiller peptide SS31is a small, cell-permeable tetrapeptide that partitions to the inner mitochondrial membrane and exerts it effects by directly ... While research has generally shown a favorable safety profile, understanding appropriate dosages, potential side effects, and long-term impacts is crucial. Clinical studies are vital for establishing its efficacy and safety for human use.作者：MD Campbell·2019·被引用次数：138—Treatment withSS-31restores redox homeostasis, improves mitochondrial quality, and increases exercise tolerance without an increase in mitochondrial content. The ongoing research and development of SS-31, including its potential approval for specific conditions, highlight its significant promise as a therapeutic peptide for a variety of health challenges rooted in mitochondrial dysfunction.
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