redv peptide is used to endothelialize the lumen of artificial blood vessels - Redapeptide Fibronectin fragment that supports binding of melanoma cells REDV Peptide: Understanding its Role in Endothelial Cell Adhesion and Biomedical Applications

Retatrutidepeptide The REDV peptide, a short sequence of amino acids (Arg-Glu-Asp-Val), plays a crucial role in biological processes, particularly in promoting the adhesion and spreading of human umbilical vein endothelial cells (HUVECs). This specific peptide is derived from the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin, a key protein involved in cell adhesion and extracellular matrix organization. The inherent ability of the REDV peptide to interact with endothelial cells has positioned it as a valuable tool in various biomedical research and development efforts, especially in areas related to vascular tissue engineering and targeted drug delivery.

The Biological Significance of REDV Peptide

At its core, the REDV peptide's primary function is to facilitate the specific binding of endothelial cells. This interaction is mediated by integrin receptors, particularly the $\alpha$4$\beta$1 integrin, which is highly expressed on HUVECs作者：L Chen·2018·被引用次数：46—22 The synthetic peptide sequenceArg-Glu-Asp-Val (REDV) is known for its specific recognition by integrin α4β1 which is abundant in endothelial .... By mimicking natural binding sites within fibronectin, the REDV peptide effectively promotes endothelial cell adhesion and spreading on surfaces where it is immobilized.Peptide REDV-Modified Polysaccharide Hydrogel with ... This characteristic is vital for applications aiming to enhance the biocompatibility of medical devices or promote the regeneration of vascular tissues.Targeting REDV peptide functionalized polycationic gene ... Research has demonstrated that REDV peptide-modified scaffolds can significantly improve endothelial cell proliferation and angiogenesis, making them promising for the development of artificial blood vessels and other cardiovascular implantsREDV ；107978-83-6 - 楚肽生物科技.

Furthermore, the REDV peptide has also been shown to support the binding of certain cell types, such as melanoma cells, suggesting a broader role in cell-surface interactions that may be relevant in cancer research作者：L Chen·2018·被引用次数：46—22 The synthetic peptide sequenceArg-Glu-Asp-Val (REDV) is known for its specific recognition by integrin α4β1 which is abundant in endothelial .... The minimal active sequence of the REDV peptide is also found in its TFA (trifluoroacetic acid) salt form, which is commonly used in scientific research for its stability and solubility作者：PX Zheng·2022·被引用次数：1—In this study, a shortpeptideArg-Glu-Asp-Val (REDV) with specific affinity for endothelial cells was covalently conjugated with maleimide-functionalized ....

Applications in Biomedical Engineering and Drug Delivery

The unique properties of the REDV peptide have led to its exploration in several advanced biomedical applications. One significant area is the modification of biomaterials to improve their endothelialization.Zwitterionic polycarboxybetaine coating functionalized with ... For instance, REDV peptide-conjugated nanoparticles have been developed as active targeting gene carriers, aiming to deliver therapeutic agents specifically to endothelial cells or sites of vascular damage2025年2月19日—REDV 是由4 个氨基酸组成的线性短肽。精氨酸的胍基结构较大且带正电，在分子间相互作用中可能通过静电作用与带负电的基团 .... This targeted approach can enhance the efficacy of treatments while minimizing off-target effects作者：A Mahara·2020·被引用次数：17—TheREDV peptideon the luminal surface of the graft was found to not only capture REDV-specific cells circulating in the blood but also inhibit ....

In vascular tissue engineering, REDV peptide-modified hydrogels and synthetic grafts are being investigated for their ability to promote the formation of a functional endotheliumImpact of REDV peptide density and its linker structure on .... By creating surfaces that readily attract and support endothelial cell growth, these materials can help prevent complications like thrombosis and inflammation, which are common challenges with artificial vascular implants. Studies have shown that REDV peptide immobilization on the luminal surface of small-diameter synthetic vascular grafts can effectively reduce early-stage fibrin clot deposition and promote endothelialization.

Moreover, the REDV peptide's ability to enhance cell uptake has also been leveraged in gene delivery systems.Targeting REDV peptide functionalized polycationic gene ... Polycationic polymers functionalized with REDV peptides have demonstrated high transfection efficiency, indicating their potential as carriers for delivering genetic material into target cells. The specific affinity of the REDV peptide for endothelial cells makes these systems particularly promising for vascular gene therapy applications.REDV–polyethyleneimine complexes for selectively ...

Considerations and Future Directions

While the REDV peptide offers significant advantages in biomedical applications, several factors warrant consideration2025年7月15日—Peptide REDV of the IIICS Region of Plasma FibronectinIs Mediated ... grafted Arg-Glu-Asp-Val (REDV) peptide (Hubbell, J. A., Massia, S. P .... The density and orientation of the REDV peptide on modified surfaces can influence its effectiveness, as highlighted in studies investigating the impact of linker structures and peptide density on cell capture. Optimizing these parameters is crucial for maximizing the desired biological responseR-E-D-V Peptide.

The scientific literature also indicates that REDV peptide shares similarities with the RGD (Arg-Gly-Asp) peptide motif, another well-known peptide involved in cell adhesion.作者：W Wang·2015·被引用次数：95—In this study, we developed apeptideGREDV-modified scaffold for selective adhesion of human umbilical vein endothelial cells (HUVECs) through the specific ... While both peptides interact with integrins, REDV exhibits a more specific affinity for endothelial cells through its interaction with $\alpha$4$\beta$1 integrin. This specificity is a key advantage in applications requiring selective targeting of vascular endothelium.

As research progresses, the REDV peptide continues to be a subject of intense study, with ongoing efforts to refine its synthesis, conjugation methods, and application in diverse therapeutic and regenerative medicine strategies. Its ability to promote endothelial cell adhesion and its specific targeting capabilities position it as a vital component in the development of next-generation biomaterials and targeted therapies.作者：Y Ji·2012·被引用次数：103—Zwitterionic polycarboxybetaine coating functionalized withREDV peptideto improve selectivity for endothelial cells. J Biomed Mater Res Part A ...